Postnatal Changes in the Expression and Localization of Jmjd3 in the Mouse Submandibular Gland

The development of the submandibular gland is mediated by epithelial-mesenchymal interactions; acini and ducts are immature at birth proliferate differentiate after birth. Limited information available on epigenetic modifications via histone during early phase salivary development. Therefore, present study examined changes in expression localization Jmjd3 to clarify role H3K27me3 modification postnatal mice. Morphological, immunohistochemical, molecular biological assays were performed using glands harvested from mice day 0 10 weeks age. On 0, characterized presence terminal tubules within abundant connective tissue. proliferation differentiation ductal cells peaked 7, structure matured mimic that adult 28. Jmjd3-positive mostly found tissue 0. After most these detected ducts. As continued develop, number Jmjd3-positve significantly decreased irrespective location. mRNA level increase until 7 gradually 14. Collectively, results demonstrated mouse concurrent with significant period. demethylation occur as develops.